Method to detect differentially methylated loci with case-control designs using Illumina arrays
نویسندگان
چکیده
منابع مشابه
Semiparametric tests for identifying differentially methylated loci with case-control designs using Illumina arrays.
DNA methylation plays an important role in the development of many types of cancer. Identifying differentially methylated loci between cancer and normal patients is one of the central tasks to understand the contributions of the methylation process on cancer development. Through investigation of the methylation measurements generated by the Illumina methylation arrays, we notice that the methyl...
متن کاملA new statistical approach to detecting differentially methylated loci for case control Illumina array methylation data
MOTIVATION As an epigenetic alteration, DNA methylation plays an important role in epigenetic controls of gene transcription. Recent advances in genome-wide scan of DNA methylation provide great opportunities in studying the impact of DNA methylation on many human diseases including various types of cancer. Due to the unique feature of this type of data, applicable statistical methods are limit...
متن کاملA Bayesian hierarchical model to detect differentially methylated loci from single nucleotide resolution sequencing data
DNA methylation is an important epigenetic modification that has essential roles in cellular processes including gene regulation, development and disease and is widely dysregulated in most types of cancer. Recent advances in sequencing technology have enabled the measurement of DNA methylation at single nucleotide resolution through methods such as whole-genome bisulfite sequencing and reduced ...
متن کاملA convenient method to generate methylated and un-methylated control DNA in methylation studies
Methylated and un-methylated control DNA is an important part of DNA methylation studies. Although human and mouse DNA methylation control sets are commercially available, in case of methylation studies on other species such as animals, plants, and bacteria, control sets need to be prepared. In this paper a simple method of generating methylated and un-methylated control DNA is described. Whole...
متن کاملStatistical methods for detecting differentially methylated loci and regions
DNA methylation, the reversible addition of methyl groups at CpG dinucleotides, represents an important regulatory layer associated with gene expression. Changed methylation status has been noted across diverse pathological states, including cancer. The rapid development and uptake of microarrays and large scale DNA sequencing has prompted an explosion of data analytic methods for processing an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genetic Epidemiology
سال: 2011
ISSN: 0741-0395
DOI: 10.1002/gepi.20619